Chinook salmon haven't been able to reach the McCloud River since 1942, when the construction of Shasta Dam blocked the fish from swimming upstream in the Sacramento River and sealed off their spawning areas, leaving the population in decline.

Source: https://phys.org/news/2023-05-tribe-pact-california-efforts-endangered.html

Kamandi took a great concept in and made it into one of the Bronze Age's best creations, but it was always swimming upstream, especially with younger readers.

Source: https://www.cbr.com/jack-kirby-kamandi-underrated-classic-dc-comic/

Radio is NOT a Wall Street business, and those who are in it are swimming upstream to try to prove that it is.

Source: https://radioink.com/2023/08/28/mike-mcvay-five-ways-to-bring-radios-enthusiasm-back/